Dual centrifugation is a highly efficient method for mixing or homogenizing samples in closed sample vials.The method is based on the classical centrifugation extended by the peculiarity that the sample vials additionally rotate around their own axis. The matrix as well as the shape and size of the sample vials result in very intensive and complex sample movements. These can be used for homogenizing and mixing, but also for extracting, grinding, dispersing, dissolving or for tissue disruption.